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Retatrutide's Phase 2 trial data (Jastreboff et al., NEJM 2023) identified a side-effect profile broadly consistent with other incretin-based therapies: Gastrointestinal : Nausea, vomiting, diarrhoea, and constipation were the most commonly reported adverse effects, particularly during dose escalation

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Inject diluent slowly down the inside wall of the vial do not shake vigorously

Those observations are included here only to summarize research context

Whatever the reason, the clinical development program ended

Its considered the safest choice for both adults and children, regardless of age, gender, ethnicity, or BMI